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Interactions médicamenteuses

Aluminum hydroxide + Cholecalciferol

Gravité: Modérée

Aluminum hydroxide and Cholecalciferol: moderate interaction.

Dernière mise à jour

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Résumé

Vitamin D increases intestinal absorption of aluminum, and chronic use of aluminum-containing antacids can lead to aluminum accumulation. This is most important in renal impairment, where aluminum toxicity can cause bone disease and neurotoxicity.

Ce que signifie cette interaction, en termes simples

Aluminum hydroxide and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Aluminum hydroxide belongs to Gastrointestinal Tract; Cholecalciferol belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Vitamin D enhances gastrointestinal aluminum absorption, and aluminum is poorly excreted in renal failure.

Conduite à tenir

Avoid long-term aluminum antacids in patients taking vitamin D, particularly with renal impairment; use a non-aluminum alternative.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Aluminum hydroxide with Cholecalciferol?

MediHelp rates the interaction as moderate. Aluminum hydroxide and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal absorption of aluminum, and chronic use of aluminum-containing antacids can lead to aluminum accumulation. This is most important in renal impairment, where aluminum toxicity can cause bone disease and neurotoxicity.

How serious is the interaction between Aluminum hydroxide and Cholecalciferol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term aluminum antacids in patients taking vitamin D, particularly with renal impairment; use a non-aluminum alternative.

What other medicines interact with Cholecalciferol?

MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Calcium acetate, Calcium Carbonate. The full list is on the Cholecalciferol page.

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