Interactions médicamenteuses
Cholecalciferol + Digoxin
Gravité: Majeure
Cholecalciferol and Digoxin: major interaction.
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Résumé
Vitamin D-induced hypercalcemia increases myocardial sensitivity to digoxin and can precipitate arrhythmias. The risk is greatest with high-dose vitamin D or active analogs.
Ce que signifie cette interaction, en termes simples
Cholecalciferol and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholecalciferol belongs to Musculoskeletal; Digoxin belongs to Cardiovascular.
Pourquoi elle survient
Hypercalcemia augments digoxin's cardiac effects, increasing digoxin toxicity risk.
Conduite à tenir
Monitor serum calcium and digoxin toxicity signs, and keep vitamin D doses modest; adjust therapy if calcium rises.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Questions fréquentes
Can I take Cholecalciferol with Digoxin?
MediHelp rates the interaction as major. Cholecalciferol and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin D-induced hypercalcemia increases myocardial sensitivity to digoxin and can precipitate arrhythmias. The risk is greatest with high-dose vitamin D or active analogs.
How serious is the interaction between Cholecalciferol and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and digoxin toxicity signs, and keep vitamin D doses modest; adjust therapy if calcium rises.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium Carbonate. The full list is on the Cholecalciferol page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
