Interactions médicamenteuses
Calcium Carbonate + Cholecalciferol
Gravité: Modérée
Calcium Carbonate and Cholecalciferol: moderate interaction.
Dernière mise à jour
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Résumé
Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements can raise serum and urinary calcium. At usual doses the combination is intended and safe, but excessive doses or predisposing conditions can cause hypercalcemia, hypercalciuria and kidney stones.
Ce que signifie cette interaction, en termes simples
Calcium Carbonate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium Carbonate belongs to Gastrointestinal Tract; Cholecalciferol belongs to Musculoskeletal.
Pourquoi elle survient
Pharmacodynamic: cholecalciferol, via calcitriol, enhances active intestinal calcium absorption, adding to the calcium supplied by calcium carbonate.
Conduite à tenir
Use the lowest doses that meet requirements and avoid combined excessive intake from diet, supplements and fortified products. Monitor serum calcium, and urinary calcium or renal function where there is a history of stones, CKD or high-dose vitamin D.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Références
- Calcium carbonate and cholecalciferol chewable tablets SmPC - Special Warnings and Interactions — EMA SmPC
Autres interactions de Calcium Carbonate
Autres interactions de Cholecalciferol
Questions fréquentes
Can I take Calcium Carbonate with Cholecalciferol?
MediHelp rates the interaction as moderate. Calcium Carbonate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements can raise serum and urinary calcium. At usual doses the combination is intended and safe, but excessive doses or predisposing conditions can cause hypercalcemia, hypercalciuria and kidney stones.
How serious is the interaction between Calcium Carbonate and Cholecalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest doses that meet requirements and avoid combined excessive intake from diet, supplements and fortified products. Monitor serum calcium, and urinary calcium or renal function where there is a history of stones, CKD or high-dose vitamin D.
What other medicines interact with Calcium Carbonate?
MediHelp also lists interactions of Calcium Carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium Carbonate page.
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