Interactions médicamenteuses
Aluminum hydroxide + Penicillamine
Gravité: Modérée
Aluminum hydroxide and Penicillamine: moderate interaction.
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Résumé
Aluminum-containing antacids reduce the absorption of penicillamine, which can lower its therapeutic effect in Wilson disease, cystinuria or rheumatoid arthritis. The effect is clinically relevant when doses are close together.
Ce que signifie cette interaction, en termes simples
Aluminum hydroxide and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Penicillamine belongs to Musculoskeletal.
Pourquoi elle survient
Aluminum chelates or adsorbs penicillamine in the gut, reducing its oral absorption.
Conduite à tenir
Separate penicillamine and the antacid by at least 2 hours. Monitor clinical response, such as urinary copper or cystine, if antacids are used regularly.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Aluminum hydroxide
Autres interactions de Penicillamine
- Gold sodium thiomalate + Penicillamine Majeure
- Calcium carbonate + Penicillamine Modérée
- Calcium + Penicillamine Modérée
- Carbonyl iron + Penicillamine Modérée
- Copper + Penicillamine Modérée
- Digoxin + Penicillamine Modérée
Questions fréquentes
Can I take Aluminum hydroxide with Penicillamine?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum-containing antacids reduce the absorption of penicillamine, which can lower its therapeutic effect in Wilson disease, cystinuria or rheumatoid arthritis. The effect is clinically relevant when doses are close together.
How serious is the interaction between Aluminum hydroxide and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate penicillamine and the antacid by at least 2 hours. Monitor clinical response, such as urinary copper or cystine, if antacids are used regularly.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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