Interactions médicamenteuses
Digoxin + Penicillamine
Gravité: Modérée
Digoxin and Penicillamine: moderate interaction.
Dernière mise à jour
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Résumé
Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.
Ce que signifie cette interaction, en termes simples
Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Penicillamine belongs to Musculoskeletal.
Pourquoi elle survient
Mechanism not established; reduced digoxin absorption has been suggested.
Conduite à tenir
Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Penicillamine
- Gold sodium thiomalate + Penicillamine Majeure
- Aluminum hydroxide + Penicillamine Modérée
- Calcium carbonate + Penicillamine Modérée
- Calcium + Penicillamine Modérée
- Carbonyl iron + Penicillamine Modérée
- Copper + Penicillamine Modérée
Autres interactions de Digoxin
- Digoxin + Lily of the valley Contre-indiquée
- Digoxin + Squill Contre-indiquée
- Adagrasib + Digoxin Majeure
- Amiodarone + Digoxin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Majeure
- Amphotericin b deoxycholate + Digoxin Majeure
Questions fréquentes
Can I take Digoxin with Penicillamine?
MediHelp rates the interaction as moderate. Digoxin and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillamine has been reported to lower serum digoxin concentrations, which could reduce control of heart rate or heart failure symptoms. The reports are limited and the mechanism is uncertain.
How serious is the interaction between Digoxin and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and clinical response when penicillamine is started or stopped. Increase the digoxin dose if needed, and separate dosing times.
What other medicines interact with Penicillamine?
MediHelp also lists interactions of Penicillamine with, for example, Gold sodium thiomalate, Aluminum hydroxide, Calcium carbonate. The full list is on the Penicillamine page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
