Interactions médicamenteuses
Amikacin + Cefazolin
Gravité: Modérée
Amikacin and Cefazolin: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Amikacin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some cases. Cefazolin has relatively low nephrotoxic potential, but the combination is used together often enough that kidney function needs attention.
Ce que signifie cette interaction, en termes simples
Amikacin and Cefazolin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefazolin belongs to Anti Bacterial.
Pourquoi elle survient
Possible additive renal tubular injury; aminoglycoside toxicity is the dominant contributor.
Conduite à tenir
Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose to renal function and minimize treatment duration.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Amikacin et Cefazolin, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Cefazolin
- Bcg vaccine live + Cefazolin Modérée
- Cefazolin + Cholera vaccine Modérée
- Cefazolin + Dexamethasone-tobramycin Modérée
- Cefazolin + Gentamicin Modérée
- Cefazolin + Kanamycin Modérée
- Cefazolin + Microbiota Modérée
Autres interactions de Amikacin
- Amikacin + Cidofovir Contre-indiquée
- Adefovir + Amikacin Majeure
- Amikacin + Amphotericin b Majeure
- Amikacin + Amphotericin b deoxycholate Majeure
- Amikacin + Atracurium Majeure
- Amikacin + Bacitracin Majeure
Questions fréquentes
Can I take Amikacin with Cefazolin?
MediHelp rates the interaction as moderate. Amikacin and Cefazolin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some cases. Cefazolin has relatively low nephrotoxic potential, but the combination is used together often enough that kidney function needs attention.
How serious is the interaction between Amikacin and Cefazolin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose to renal function and minimize treatment duration.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Bcg vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefazolin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
