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Interactions médicamenteuses

Cefazolin + Cholera vaccine

Gravité: Modérée

Cefazolin and Cholera vaccine: moderate interaction.

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Résumé

The oral live attenuated cholera vaccine can be inactivated by active antibiotics, reducing immune response. A single perioperative cefazolin dose is less likely to matter but the labeling advice still applies.

Ce que signifie cette interaction, en termes simples

Cefazolin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Niveau de preuve: Moderate

Pourquoi elle survient

Antibacterial activity against the live attenuated vaccine strain reduces its replication and immunogenicity.

Conduite à tenir

Avoid vaccination within 14 days of systemic antibiotic use, as per labeling; defer the vaccine until the course is completed.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cefazolin with Cholera vaccine?

MediHelp rates the interaction as moderate. Cefazolin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine can be inactivated by active antibiotics, reducing immune response. A single perioperative cefazolin dose is less likely to matter but the labeling advice still applies.

How serious is the interaction between Cefazolin and Cholera vaccine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination within 14 days of systemic antibiotic use, as per labeling; defer the vaccine until the course is completed.

What other medicines interact with Cefazolin?

MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Dexamethasone-tobramycin. The full list is on the Cefazolin page.

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