Interactions médicamenteuses
Cefazolin + Gentamicin
Gravité: Modérée
Cefazolin and Gentamicin: moderate interaction.
Dernière mise à jour
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Résumé
Giving cefazolin with gentamicin may raise the risk of kidney injury, mainly in patients who are elderly, volume-depleted or have existing renal impairment. The aminoglycoside is the principal nephrotoxic and ototoxic agent, and the combination is often used deliberately, for example in endocarditis.
Ce que signifie cette interaction, en termes simples
Cefazolin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefazolin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Pourquoi elle survient
Additive nephrotoxic potential; cephalosporins may modestly add to aminoglycoside tubular injury.
Conduite à tenir
Monitor serum creatinine and gentamicin levels, keep the patient well hydrated and limit the duration of aminoglycoside therapy. Adjust the doses for renal function.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefazolin
- Amikacin + Cefazolin Modérée
- Bcg vaccine live + Cefazolin Modérée
- Cefazolin + Cholera vaccine Modérée
- Cefazolin + Dexamethasone-tobramycin Modérée
- Cefazolin + Kanamycin Modérée
- Cefazolin + Microbiota Modérée
Autres interactions de Gentamicin
- Cidofovir + Gentamicin Contre-indiquée
- Adefovir + Gentamicin Majeure
- Amikacin + Gentamicin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Majeure
- Amphotericin b deoxycholate + Gentamicin Majeure
- Amphotericin b + Gentamicin Majeure
Questions fréquentes
Can I take Cefazolin with Gentamicin?
MediHelp rates the interaction as moderate. Cefazolin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving cefazolin with gentamicin may raise the risk of kidney injury, mainly in patients who are elderly, volume-depleted or have existing renal impairment. The aminoglycoside is the principal nephrotoxic and ototoxic agent, and the combination is often used deliberately, for example in endocarditis.
How serious is the interaction between Cefazolin and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, keep the patient well hydrated and limit the duration of aminoglycoside therapy. Adjust the doses for renal function.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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