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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Amiodarone + Nilotinib

Gravité: Contre-indiquée

Amiodarone and Nilotinib: contraindicated interaction.

Dernière mise à jour

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Résumé

Nilotinib carries a boxed warning for QT prolongation and sudden death, and amiodarone also prolongs QT. Amiodarone is a CYP3A4 substrate, and nilotinib inhibits CYP3A4, which may raise amiodarone levels and further increase risk.

Ce que signifie cette interaction, en termes simples

Amiodarone and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amiodarone belongs to Cardiovascular; Nilotinib belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Additive QT prolongation plus CYP3A4 inhibition by nilotinib increasing amiodarone exposure.

Conduite à tenir

Do not combine; use an alternative antiarrhythmic or kinase inhibitor. If no alternative exists, require specialist oversight with frequent ECGs and electrolyte correction.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Nilotinib?

MediHelp rates the interaction as contraindicated. Amiodarone and Nilotinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nilotinib carries a boxed warning for QT prolongation and sudden death, and amiodarone also prolongs QT. Amiodarone is a CYP3A4 substrate, and nilotinib inhibits CYP3A4, which may raise amiodarone levels and further increase risk.

How serious is the interaction between Amiodarone and Nilotinib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antiarrhythmic or kinase inhibitor. If no alternative exists, require specialist oversight with frequent ECGs and electrolyte correction.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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