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Interactions médicamenteuses

Amiodarone + Rifaximin

Gravité: Modérée

Amiodarone and Rifaximin: moderate interaction.

Dernière mise à jour

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Résumé

Amiodarone inhibits P-glycoprotein and may increase systemic rifaximin absorption. Rifaximin's systemic exposure is normally very low, so the effect is of limited importance except in severe liver disease.

Ce que signifie cette interaction, en termes simples

Amiodarone and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amiodarone belongs to Cardiovascular; Rifaximin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

P-glycoprotein inhibition by amiodarone reduces intestinal efflux of rifaximin.

Conduite à tenir

Rifaximin labeling advises caution with P-gp inhibitors in hepatic impairment; monitor for rifaximin adverse effects and avoid unnecessary dose escalation.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Rifaximin?

MediHelp rates the interaction as moderate. Amiodarone and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and may increase systemic rifaximin absorption. Rifaximin's systemic exposure is normally very low, so the effect is of limited importance except in severe liver disease.

How serious is the interaction between Amiodarone and Rifaximin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Rifaximin labeling advises caution with P-gp inhibitors in hepatic impairment; monitor for rifaximin adverse effects and avoid unnecessary dose escalation.

What other medicines interact with Rifaximin?

MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Bcg intravesical live. The full list is on the Rifaximin page.

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