Interactions médicamenteuses
Amisulpride + Solifenacin
Gravité: Majeure
Amisulpride and Solifenacin: major interaction.
Dernière mise à jour
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Résumé
Amisulpride prolongs the QT interval in a dose-related way, and solifenacin has been associated with QT prolongation at supratherapeutic doses. Combined use may increase the risk of ventricular arrhythmias, particularly with other risk factors.
Ce que signifie cette interaction, en termes simples
Amisulpride and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Pourquoi elle survient
Additive QT-interval prolongation.
Conduite à tenir
Obtain an ECG and check potassium and magnesium before starting, and monitor during co-therapy. Avoid it in patients with congenital long QT, bradycardia, or hypokalemia.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Solifenacin
- Adagrasib + Solifenacin Majeure
- Amiodarone + Solifenacin Majeure
- Anagrelide + Solifenacin Majeure
- Arsenic trioxide + Solifenacin Majeure
- Bedaquiline + Solifenacin Majeure
- Ceritinib + Solifenacin Majeure
Autres interactions de Amisulpride
- Amiodarone + Amisulpride Contre-indiquée
- Amisulpride + Arsenic trioxide Contre-indiquée
- Amisulpride + Disopyramide Contre-indiquée
- Amisulpride + Dofetilide Contre-indiquée
- Amisulpride + Droperidol Contre-indiquée
- Amisulpride + Ibutilide Contre-indiquée
Questions fréquentes
Can I take Amisulpride with Solifenacin?
MediHelp rates the interaction as major. Amisulpride and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride prolongs the QT interval in a dose-related way, and solifenacin has been associated with QT prolongation at supratherapeutic doses. Combined use may increase the risk of ventricular arrhythmias, particularly with other risk factors.
How serious is the interaction between Amisulpride and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check potassium and magnesium before starting, and monitor during co-therapy. Avoid it in patients with congenital long QT, bradycardia, or hypokalemia.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Anagrelide. The full list is on the Solifenacin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
