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Interactions médicamenteuses

Amitriptyline + Ziprasidone

Gravité: Contre-indiquée

Amitriptyline and Ziprasidone: contraindicated interaction.

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Résumé

Both agents prolong the QT interval, so combined use increases the risk of torsades de pointes and sudden cardiac death. Ziprasidone labeling advises against combining it with other QT-prolonging drugs.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amitriptyline belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT interval prolongation.

Conduite à tenir

Avoid the combination and choose an antipsychotic or antidepressant with less QT effect. If this cannot be avoided, correct electrolytes and monitor the ECG closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Ziprasidone?

MediHelp rates the interaction as contraindicated. Amitriptyline and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, so combined use increases the risk of torsades de pointes and sudden cardiac death. Ziprasidone labeling advises against combining it with other QT-prolonging drugs.

How serious is the interaction between Amitriptyline and Ziprasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic or antidepressant with less QT effect. If this cannot be avoided, correct electrolytes and monitor the ECG closely.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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