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Interactions médicamenteuses

Chloroquine + Ziprasidone

Gravité: Contre-indiquée

Chloroquine and Ziprasidone: contraindicated interaction.

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Résumé

Ziprasidone is known for QT prolongation and its labeling advises against use with other QT-prolonging drugs. Adding chloroquine increases the risk of torsades de pointes and sudden cardiac death.

Ce que signifie cette interaction, en termes simples

Chloroquine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Chloroquine belongs to Anti Parasitic; Ziprasidone belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive blockade of cardiac potassium channels leading to delayed repolarization.

Conduite à tenir

Avoid the combination and use a different antipsychotic or antimalarial. Ziprasidone labeling lists other QT-prolonging drugs as contraindicated.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Chloroquine with Ziprasidone?

MediHelp rates the interaction as contraindicated. Chloroquine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is known for QT prolongation and its labeling advises against use with other QT-prolonging drugs. Adding chloroquine increases the risk of torsades de pointes and sudden cardiac death.

How serious is the interaction between Chloroquine and Ziprasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a different antipsychotic or antimalarial. Ziprasidone labeling lists other QT-prolonging drugs as contraindicated.

What other medicines interact with Chloroquine?

MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.

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