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Interactions médicamenteuses

Amlodipine-hydrochlorothiazide-valsartan + Digoxin

Gravité: Majeure

Amlodipine-hydrochlorothiazide-valsartan and Digoxin: major interaction.

Dernière mise à jour

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Résumé

Hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and the risk of arrhythmias. Valsartan-related renal changes may also modestly raise digoxin levels.

Ce que signifie cette interaction, en termes simples

Amlodipine-hydrochlorothiazide-valsartan and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Digoxin belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Diuretic-induced hypokalemia and hypomagnesemia enhance digoxin toxicity, with possible reduced renal digoxin clearance.

Conduite à tenir

Monitor potassium, magnesium and renal function regularly and keep potassium in the normal range. Check digoxin levels and watch for toxicity symptoms.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amlodipine-hydrochlorothiazide-valsartan with Digoxin?

MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydrochlorothiazide-induced hypokalemia and hypomagnesemia increase myocardial sensitivity to digoxin and the risk of arrhythmias. Valsartan-related renal changes may also modestly raise digoxin levels.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Digoxin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium and renal function regularly and keep potassium in the normal range. Check digoxin levels and watch for toxicity symptoms.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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