Interactions médicamenteuses
Amphotericin b + Digoxin
Gravité: Majeure
Amphotericin b and Digoxin: major interaction.
Dernière mise à jour
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Résumé
Amphotericin B often causes hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin. This can precipitate digoxin toxicity with arrhythmias even at normal serum digoxin levels.
Ce que signifie cette interaction, en termes simples
Amphotericin b and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Digoxin belongs to Cardiovascular.
Pourquoi elle survient
Electrolyte depletion (potassium, magnesium) from amphotericin B increases digoxin cardiac sensitivity.
Conduite à tenir
Monitor potassium and magnesium frequently and keep them in the normal range with supplements. Check digoxin levels and ECG, and watch for signs of toxicity.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amphotericin b
- Amphotericin b + Cidofovir Contre-indiquée
- Adefovir + Amphotericin b Majeure
- Amikacin + Amphotericin b Majeure
- Amphotericin b + Arsenic trioxide Majeure
- Amphotericin b + Capreomycin Majeure
- Amphotericin b + Cephaloridine Majeure
Autres interactions de Digoxin
- Digoxin + Lily of the valley Contre-indiquée
- Digoxin + Squill Contre-indiquée
- Adagrasib + Digoxin Majeure
- Amiodarone + Digoxin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Majeure
- Amphotericin b deoxycholate + Digoxin Majeure
Questions fréquentes
Can I take Amphotericin b with Digoxin?
MediHelp rates the interaction as major. Amphotericin b and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphotericin B often causes hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin. This can precipitate digoxin toxicity with arrhythmias even at normal serum digoxin levels.
How serious is the interaction between Amphotericin b and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium frequently and keep them in the normal range with supplements. Check digoxin levels and ECG, and watch for signs of toxicity.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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