Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Losartan
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Losartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining losartan with a product that already contains olmesartan means two angiotensin receptor blockers are used together. This gives no meaningful added benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade produces additive hypotensive, renal and potassium-retaining effects.
What to do
Avoid concurrent use of two angiotensin receptor blockers and discontinue one of them. If an overlap occurs, check blood pressure, serum potassium and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Losartan?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining losartan with a product that already contains olmesartan means two angiotensin receptor blockers are used together. This gives no meaningful added benefit and increases the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two angiotensin receptor blockers and discontinue one of them. If an overlap occurs, check blood pressure, serum potassium and creatinine.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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