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Interactions médicamenteuses

Amlodipine-perindopril + Candesartan

Gravité: Majeure

Amlodipine-perindopril and Candesartan: major interaction.

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Résumé

Perindopril with candesartan produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment without added clinical benefit in most patients.

Ce que signifie cette interaction, en termes simples

Amlodipine-perindopril and Candesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amlodipine-perindopril belongs to Cardiovascular; Candesartan belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive inhibition of the renin-angiotensin-aldosterone system by ACE inhibition and angiotensin receptor blockade.

Conduite à tenir

Avoid the combination in most patients. Where it is used, for example in selected heart failure cases, monitor potassium, creatinine and blood pressure closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amlodipine-perindopril with Candesartan?

MediHelp rates the interaction as major. Amlodipine-perindopril and Candesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Perindopril with candesartan produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment without added clinical benefit in most patients.

How serious is the interaction between Amlodipine-perindopril and Candesartan?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in most patients. Where it is used, for example in selected heart failure cases, monitor potassium, creatinine and blood pressure closely.

What other medicines interact with Amlodipine-perindopril?

MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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