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Interactions médicamenteuses

Amobarbital + Ethinyl estradiol-levonorgestrel

Gravité: Majeure

Amobarbital and Ethinyl estradiol-levonorgestrel: major interaction.

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Résumé

Barbiturates induce liver enzymes and lower contraceptive hormone concentrations. This can lead to breakthrough bleeding and contraceptive failure.

Ce que signifie cette interaction, en termes simples

Amobarbital and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amobarbital belongs to Central Nervous System; Ethinyl estradiol-levonorgestrel belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP3A4 by amobarbital increases metabolism of ethinyl estradiol and levonorgestrel.

Conduite à tenir

Use a non-hormonal contraceptive such as a copper IUD instead of relying on the pill during and after barbiturate treatment.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amobarbital with Ethinyl estradiol-levonorgestrel?

MediHelp rates the interaction as major. Amobarbital and Ethinyl estradiol-levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce liver enzymes and lower contraceptive hormone concentrations. This can lead to breakthrough bleeding and contraceptive failure.

How serious is the interaction between Amobarbital and Ethinyl estradiol-levonorgestrel?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal contraceptive such as a copper IUD instead of relying on the pill during and after barbiturate treatment.

What other medicines interact with Ethinyl estradiol-levonorgestrel?

MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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