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Interactions médicamenteuses

Amobarbital + Etravirine

Gravité: Majeure

Amobarbital and Etravirine: major interaction.

Dernière mise à jour

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Résumé

Barbiturates are enzyme inducers and can substantially reduce etravirine concentrations, risking loss of antiviral efficacy and resistance. Etravirine labeling advises against combination with phenobarbital, and other barbiturates are expected to act similarly.

Ce que signifie cette interaction, en termes simples

Amobarbital and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amobarbital belongs to Central Nervous System; Etravirine belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP3A4, CYP2C9 and CYP2C19 by the barbiturate accelerates etravirine metabolism.

Conduite à tenir

Avoid the combination and choose a non-inducing sedative or anticonvulsant. If it cannot be avoided, monitor HIV viral load closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amobarbital with Etravirine?

MediHelp rates the interaction as major. Amobarbital and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates are enzyme inducers and can substantially reduce etravirine concentrations, risking loss of antiviral efficacy and resistance. Etravirine labeling advises against combination with phenobarbital, and other barbiturates are expected to act similarly.

How serious is the interaction between Amobarbital and Etravirine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing sedative or anticonvulsant. If it cannot be avoided, monitor HIV viral load closely.

What other medicines interact with Amobarbital?

MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.

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