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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Deflazacort + Etravirine

Gravité: Majeure

Deflazacort and Etravirine: major interaction.

Dernière mise à jour

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Résumé

Etravirine is a CYP3A4 inducer and may lower exposure to deflazacort's active metabolite. Reduced corticosteroid efficacy may result.

Ce que signifie cette interaction, en termes simples

Deflazacort and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Deflazacort belongs to Miscellaneous; Etravirine belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Etravirine induces CYP3A4, increasing clearance of deflazacort's active metabolite.

Conduite à tenir

Avoid concomitant use where possible. If it cannot be avoided, monitor for loss of efficacy and consider an alternative corticosteroid or dose adjustment.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deflazacort with Etravirine?

MediHelp rates the interaction as major. Deflazacort and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etravirine is a CYP3A4 inducer and may lower exposure to deflazacort's active metabolite. Reduced corticosteroid efficacy may result.

How serious is the interaction between Deflazacort and Etravirine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible. If it cannot be avoided, monitor for loss of efficacy and consider an alternative corticosteroid or dose adjustment.

What other medicines interact with Deflazacort?

MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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