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Interactions médicamenteuses

Amobarbital + Sufentanil

Gravité: Majeure

Amobarbital and Sufentanil: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Barbiturates and opioids both depress the CNS and respiration, and combined use can cause profound sedation, respiratory depression, coma or death. Sufentanil is very potent, so the risk is substantial.

Ce que signifie cette interaction, en termes simples

Amobarbital and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amobarbital belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.

Niveau de preuve: High

Pourquoi elle survient

Additive CNS and respiratory depression through opioid and GABAergic pathways.

Conduite à tenir

Use only where monitored, with reduced doses and continuous assessment of respiratory rate and sedation. Have airway support and naloxone available.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Amobarbital with Sufentanil?

MediHelp rates the interaction as major. Amobarbital and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and opioids both depress the CNS and respiration, and combined use can cause profound sedation, respiratory depression, coma or death. Sufentanil is very potent, so the risk is substantial.

How serious is the interaction between Amobarbital and Sufentanil?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where monitored, with reduced doses and continuous assessment of respiratory rate and sedation. Have airway support and naloxone available.

What other medicines interact with Amobarbital?

MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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