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Interactions médicamenteuses

Amoxapine + Dicyclomine

Gravité: Modérée

Amoxapine and Dicyclomine: moderate interaction.

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Résumé

Amoxapine has anticholinergic properties, which add to those of dicyclomine. The combination may cause marked dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, particularly in older people.

Ce que signifie cette interaction, en termes simples

Amoxapine and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive muscarinic receptor blockade.

Conduite à tenir

Monitor for anticholinergic toxicity and consider a lower dicyclomine dose or a less anticholinergic alternative. Take extra care in older patients and those with glaucoma or urinary obstruction.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amoxapine with Dicyclomine?

MediHelp rates the interaction as moderate. Amoxapine and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has anticholinergic properties, which add to those of dicyclomine. The combination may cause marked dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, particularly in older people.

How serious is the interaction between Amoxapine and Dicyclomine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider a lower dicyclomine dose or a less anticholinergic alternative. Take extra care in older patients and those with glaucoma or urinary obstruction.

What other medicines interact with Dicyclomine?

MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.

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