Drug interactions
Amoxapine + Dicyclomine
Severity: Moderate
Amoxapine and Dicyclomine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has anticholinergic properties, which add to those of dicyclomine. The combination may cause marked dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, particularly in older people.
What this interaction means in plain words
Amoxapine and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity and consider a lower dicyclomine dose or a less anticholinergic alternative. Take extra care in older patients and those with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Amoxapine with Dicyclomine?
MediHelp rates the interaction as moderate. Amoxapine and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has anticholinergic properties, which add to those of dicyclomine. The combination may cause marked dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, particularly in older people.
How serious is the interaction between Amoxapine and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider a lower dicyclomine dose or a less anticholinergic alternative. Take extra care in older patients and those with glaucoma or urinary obstruction.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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