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Interactions médicamenteuses

Dicyclomine + Imipramine

Gravité: Majeure

Dicyclomine and Imipramine: major interaction.

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Résumé

Imipramine has marked anticholinergic activity, so combined use adds to the anticholinergic burden. This can produce severe constipation, ileus, urinary retention, tachycardia, blurred vision, delirium and heat intolerance.

Ce que signifie cette interaction, en termes simples

Dicyclomine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dicyclomine belongs to Respiratory; Imipramine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive antimuscarinic pharmacodynamic effects.

Conduite à tenir

Avoid the combination if possible, particularly in older adults. If used, monitor for ileus, urinary retention, confusion and tachycardia and reduce doses as needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dicyclomine with Imipramine?

MediHelp rates the interaction as major. Dicyclomine and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imipramine has marked anticholinergic activity, so combined use adds to the anticholinergic burden. This can produce severe constipation, ileus, urinary retention, tachycardia, blurred vision, delirium and heat intolerance.

How serious is the interaction between Dicyclomine and Imipramine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, particularly in older adults. If used, monitor for ileus, urinary retention, confusion and tachycardia and reduce doses as needed.

What other medicines interact with Dicyclomine?

MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Pramlintide. The full list is on the Dicyclomine page.

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