Interactions médicamenteuses
Amoxapine + Selegiline
Gravité: Contre-indiquée
Amoxapine and Selegiline: contraindicated interaction.
Dernière mise à jour
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Résumé
Selegiline is a MAO-B inhibitor that loses selectivity at higher doses and, together with a tricyclic-type antidepressant such as amoxapine, can precipitate serotonin syndrome or hypertensive reactions. Labeling for both drug classes advises against concurrent use.
Ce que signifie cette interaction, en termes simples
Amoxapine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Combined MAO inhibition and inhibition of norepinephrine and serotonin reuptake, causing excess monoaminergic activity.
Conduite à tenir
Do not co-administer; allow at least 14 days between stopping selegiline and starting amoxapine, and an adequate washout in the other direction. Seek urgent care for agitation, hyperthermia, tremor or severe hypertension.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Selegiline
- Amitriptyline + Selegiline Contre-indiquée
- Atomoxetine + Selegiline Contre-indiquée
- Benzphetamine + Selegiline Contre-indiquée
- Brimonidine + Selegiline Contre-indiquée
- Buprenorphine long-acting + Selegiline Contre-indiquée
- Bupropion-naltrexone + Selegiline Contre-indiquée
Questions fréquentes
Can I take Amoxapine with Selegiline?
MediHelp rates the interaction as contraindicated. Amoxapine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is a MAO-B inhibitor that loses selectivity at higher doses and, together with a tricyclic-type antidepressant such as amoxapine, can precipitate serotonin syndrome or hypertensive reactions. Labeling for both drug classes advises against concurrent use.
How serious is the interaction between Amoxapine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days between stopping selegiline and starting amoxapine, and an adequate washout in the other direction. Seek urgent care for agitation, hyperthermia, tremor or severe hypertension.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Atomoxetine, Benzphetamine. The full list is on the Selegiline page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
