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Interactions médicamenteuses

Atomoxetine + Selegiline

Gravité: Contre-indiquée

Atomoxetine and Selegiline: contraindicated interaction.

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Résumé

Selegiline inhibits monoamine oxidase, and atomoxetine raises synaptic noradrenaline. The combination has led to hypertensive reactions, hyperthermia, rigidity and altered consciousness.

Ce que signifie cette interaction, en termes simples

Atomoxetine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Atomoxetine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition plus noradrenaline reuptake inhibition causes excessive adrenergic stimulation

Conduite à tenir

Do not use together; wait at least 14 days after stopping a MAOI before starting atomoxetine, and 2 days the other way round.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atomoxetine with Selegiline?

MediHelp rates the interaction as contraindicated. Atomoxetine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits monoamine oxidase, and atomoxetine raises synaptic noradrenaline. The combination has led to hypertensive reactions, hyperthermia, rigidity and altered consciousness.

How serious is the interaction between Atomoxetine and Selegiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; wait at least 14 days after stopping a MAOI before starting atomoxetine, and 2 days the other way round.

What other medicines interact with Atomoxetine?

MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.

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