Interactions médicamenteuses
Buprenorphine long-acting + Selegiline
Gravité: Contre-indiquée
Buprenorphine long-acting and Selegiline: contraindicated interaction.
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Résumé
Concurrent use may cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Long-acting buprenorphine cannot be quickly withdrawn, which makes any reaction harder to manage.
Ce que signifie cette interaction, en termes simples
Buprenorphine long-acting and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
MAO inhibition combined with serotonergic opioid activity increases serotonin, and MAO inhibitors may also potentiate opioid effects.
Conduite à tenir
Do not use long-acting buprenorphine in patients taking an MAO inhibitor or within 14 days of stopping one. Choose a non-serotonergic alternative.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Selegiline
- Amitriptyline + Selegiline Contre-indiquée
- Amoxapine + Selegiline Contre-indiquée
- Atomoxetine + Selegiline Contre-indiquée
- Benzphetamine + Selegiline Contre-indiquée
- Brimonidine + Selegiline Contre-indiquée
- Bupropion-naltrexone + Selegiline Contre-indiquée
Questions fréquentes
Can I take Buprenorphine long-acting with Selegiline?
MediHelp rates the interaction as contraindicated. Buprenorphine long-acting and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concurrent use may cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Long-acting buprenorphine cannot be quickly withdrawn, which makes any reaction harder to manage.
How serious is the interaction between Buprenorphine long-acting and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use long-acting buprenorphine in patients taking an MAO inhibitor or within 14 days of stopping one. Choose a non-serotonergic alternative.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
