Interactions médicamenteuses
Benzphetamine + Selegiline
Gravité: Contre-indiquée
Benzphetamine and Selegiline: contraindicated interaction.
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Résumé
Selegiline, particularly in the transdermal form that provides non-selective MAO inhibition, can greatly amplify the sympathomimetic effects of benzphetamine. This may precipitate a hypertensive crisis with severe headache, arrhythmia or intracranial haemorrhage.
Ce que signifie cette interaction, en termes simples
Benzphetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
MAO inhibition allows accumulation of norepinephrine and other monoamines, and benzphetamine adds indirect sympathomimetic release, producing additive pressor effects.
Conduite à tenir
Do not co-administer; benzphetamine labeling contraindicates use during or within 14 days of an MAO inhibitor. Choose a non-sympathomimetic weight management approach.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Selegiline
- Amitriptyline + Selegiline Contre-indiquée
- Amoxapine + Selegiline Contre-indiquée
- Atomoxetine + Selegiline Contre-indiquée
- Brimonidine + Selegiline Contre-indiquée
- Buprenorphine long-acting + Selegiline Contre-indiquée
- Bupropion-naltrexone + Selegiline Contre-indiquée
Questions fréquentes
Can I take Benzphetamine with Selegiline?
MediHelp rates the interaction as contraindicated. Benzphetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline, particularly in the transdermal form that provides non-selective MAO inhibition, can greatly amplify the sympathomimetic effects of benzphetamine. This may precipitate a hypertensive crisis with severe headache, arrhythmia or intracranial haemorrhage.
How serious is the interaction between Benzphetamine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; benzphetamine labeling contraindicates use during or within 14 days of an MAO inhibitor. Choose a non-sympathomimetic weight management approach.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
