Interactions médicamenteuses
Amphotericin b + Gentamicin
Gravité: Majeure
Amphotericin b and Gentamicin: major interaction.
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Résumé
Both drugs cause nephrotoxicity, and gentamicin also carries ototoxic and vestibulotoxic risk. Concurrent use increases the likelihood of acute kidney injury, which in turn raises aminoglycoside levels and further toxicity.
Ce que signifie cette interaction, en termes simples
Amphotericin b and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Gentamicin belongs to Anti Bacterial.
Pourquoi elle survient
Additive proximal tubular nephrotoxicity, with accumulation of gentamicin when renal function falls.
Conduite à tenir
Avoid the combination if alternatives exist. If needed, monitor creatinine and gentamicin levels closely, hydrate, and consider audiometry for prolonged courses.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amphotericin b
- Amphotericin b + Cidofovir Contre-indiquée
- Adefovir + Amphotericin b Majeure
- Amikacin + Amphotericin b Majeure
- Amphotericin b + Arsenic trioxide Majeure
- Amphotericin b + Capreomycin Majeure
- Amphotericin b + Cephaloridine Majeure
Autres interactions de Gentamicin
- Cidofovir + Gentamicin Contre-indiquée
- Adefovir + Gentamicin Majeure
- Amikacin + Gentamicin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Majeure
- Amphotericin b deoxycholate + Gentamicin Majeure
- Atracurium + Gentamicin Majeure
Questions fréquentes
Can I take Amphotericin b with Gentamicin?
MediHelp rates the interaction as major. Amphotericin b and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause nephrotoxicity, and gentamicin also carries ototoxic and vestibulotoxic risk. Concurrent use increases the likelihood of acute kidney injury, which in turn raises aminoglycoside levels and further toxicity.
How serious is the interaction between Amphotericin b and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if alternatives exist. If needed, monitor creatinine and gentamicin levels closely, hydrate, and consider audiometry for prolonged courses.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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