Interactions médicamenteuses
Amphotericin b deoxycholate + Gentamicin
Gravité: Majeure
Amphotericin b deoxycholate and Gentamicin: major interaction.
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Résumé
Both agents damage renal tubules, and together they commonly produce acute kidney injury and electrolyte loss. Impaired renal clearance may raise gentamicin levels and ototoxicity risk.
Ce que signifie cette interaction, en termes simples
Amphotericin b deoxycholate and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive nephrotoxicity from tubular injury and amphotericin-induced renal vasoconstriction.
Conduite à tenir
Avoid concurrent use if alternatives exist, such as a lipid amphotericin formulation or another antibiotic. If necessary, monitor creatinine, potassium, magnesium and gentamicin levels.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Gentamicin
- Cidofovir + Gentamicin Contre-indiquée
- Adefovir + Gentamicin Majeure
- Amikacin + Gentamicin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Majeure
- Amphotericin b + Gentamicin Majeure
- Atracurium + Gentamicin Majeure
Questions fréquentes
Can I take Amphotericin b deoxycholate with Gentamicin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents damage renal tubules, and together they commonly produce acute kidney injury and electrolyte loss. Impaired renal clearance may raise gentamicin levels and ototoxicity risk.
How serious is the interaction between Amphotericin b deoxycholate and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist, such as a lipid amphotericin formulation or another antibiotic. If necessary, monitor creatinine, potassium, magnesium and gentamicin levels.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
