Interactions médicamenteuses
Amlodipine-hydrochlorothiazide-valsartan + Gentamicin
Gravité: Majeure
Amlodipine-hydrochlorothiazide-valsartan and Gentamicin: major interaction.
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Résumé
Gentamicin can cause renal tubular damage with magnesium and potassium wasting, and hydrochlorothiazide adds to potassium and magnesium loss. Diuretic-induced volume depletion also raises the risk of aminoglycoside nephrotoxicity and ototoxicity, while valsartan can worsen renal function in volume depletion.
Ce que signifie cette interaction, en termes simples
Amlodipine-hydrochlorothiazide-valsartan and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Pourquoi elle survient
Additive renal electrolyte wasting, with diuretic volume depletion and angiotensin blockade increasing susceptibility to aminoglycoside nephrotoxicity.
Conduite à tenir
Monitor serum creatinine, potassium and magnesium, and gentamicin levels during treatment. Consider holding the diuretic and valsartan during acute illness or volume depletion.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contre-indiquée
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contre-indiquée
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contre-indiquée
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Majeure
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Majeure
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Majeure
Autres interactions de Gentamicin
- Cidofovir + Gentamicin Contre-indiquée
- Adefovir + Gentamicin Majeure
- Amikacin + Gentamicin Majeure
- Amphotericin b deoxycholate + Gentamicin Majeure
- Amphotericin b + Gentamicin Majeure
- Atracurium + Gentamicin Majeure
Questions fréquentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Gentamicin?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin can cause renal tubular damage with magnesium and potassium wasting, and hydrochlorothiazide adds to potassium and magnesium loss. Diuretic-induced volume depletion also raises the risk of aminoglycoside nephrotoxicity and ototoxicity, while valsartan can worsen renal function in volume depletion.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium, and gentamicin levels during treatment. Consider holding the diuretic and valsartan during acute illness or volume depletion.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
