Interactions médicamenteuses
Amphotericin b liposomal + Captopril-hydrochlorothiazide
Gravité: Modérée
Amphotericin b liposomal and Captopril-hydrochlorothiazide: moderate interaction.
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Résumé
Amphotericin B causes potassium and magnesium wasting and can be nephrotoxic, and hydrochlorothiazide adds to potassium loss. Together they raise the risk of significant hypokalemia, and volume depletion with captopril can worsen renal function.
Ce que signifie cette interaction, en termes simples
Amphotericin b liposomal and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Pourquoi elle survient
Additive renal potassium and magnesium wasting, with additive effects on renal hemodynamics and volume status.
Conduite à tenir
Monitor serum potassium, magnesium and creatinine regularly and replace electrolytes as needed. Reassess the need for the diuretic during amphotericin therapy.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contre-indiquée
- Captopril-hydrochlorothiazide + Dofetilide Contre-indiquée
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contre-indiquée
- Aceclofenac + Captopril-hydrochlorothiazide Majeure
- Aldesleukin + Captopril-hydrochlorothiazide Majeure
- Amifostine + Captopril-hydrochlorothiazide Majeure
Autres interactions de Amphotericin b liposomal
Questions fréquentes
Can I take Amphotericin b liposomal with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B causes potassium and magnesium wasting and can be nephrotoxic, and hydrochlorothiazide adds to potassium loss. Together they raise the risk of significant hypokalemia, and volume depletion with captopril can worsen renal function.
How serious is the interaction between Amphotericin b liposomal and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and creatinine regularly and replace electrolytes as needed. Reassess the need for the diuretic during amphotericin therapy.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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