Interactions médicamenteuses
Amphotericin b liposomal + Tenofovir disoproxil
Gravité: Modérée
Amphotericin b liposomal and Tenofovir disoproxil: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Both drugs can injure the kidney, and giving them together may add to the risk of renal impairment. Reduced kidney function can in turn raise tenofovir exposure and worsen tubular toxicity. The liposomal formulation is generally less nephrotoxic than conventional amphotericin B.
Ce que signifie cette interaction, en termes simples
Amphotericin b liposomal and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Additive nephrotoxicity, with reduced renal clearance of tenofovir when kidney function declines.
Conduite à tenir
Monitor serum creatinine, estimated creatinine clearance, phosphate and electrolytes regularly during combined use. Adjust the tenofovir interval for renal function or choose an alternative if renal function falls.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Amphotericin b liposomal et Tenofovir disoproxil, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Amphotericin b liposomal
- Amlodipine-benazepril + Amphotericin b liposomal Modérée
- Amphotericin b liposomal + Benazepril Modérée
- Amphotericin b liposomal + Captopril-hydrochlorothiazide Modérée
- Amphotericin b liposomal + Deflazacort Modérée
- Amphotericin b liposomal + Dichlorphenamide Modérée
- Amphotericin b liposomal + Ifosfamide Modérée
Questions fréquentes
Can I take Amphotericin b liposomal with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and giving them together may add to the risk of renal impairment. Reduced kidney function can in turn raise tenofovir exposure and worsen tubular toxicity. The liposomal formulation is generally less nephrotoxic than conventional amphotericin B.
How serious is the interaction between Amphotericin b liposomal and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated creatinine clearance, phosphate and electrolytes regularly during combined use. Adjust the tenofovir interval for renal function or choose an alternative if renal function falls.
What other medicines interact with Amphotericin b liposomal?
MediHelp also lists interactions of Amphotericin b liposomal with, for example, Amlodipine-benazepril, Benazepril, Captopril-hydrochlorothiazide. The full list is on the Amphotericin b liposomal page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
