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Interactions médicamenteuses

Anastrozole + Bazedoxifene-conjugated estrogens

Gravité: Contre-indiquée

Anastrozole and Bazedoxifene-conjugated estrogens: contraindicated interaction.

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Résumé

Estrogens in bazedoxifene/conjugated estrogens counteract the estrogen-lowering effect of anastrozole. Efficacy in breast cancer may be reduced.

Ce que signifie cette interaction, en termes simples

Anastrozole and Bazedoxifene-conjugated estrogens are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Anastrozole belongs to Oncology; Bazedoxifene-conjugated estrogens belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Pharmacodynamic antagonism of aromatase inhibitor effect

Conduite à tenir

Do not use together; consider non-estrogen alternatives.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Anastrozole with Bazedoxifene-conjugated estrogens?

MediHelp rates the interaction as contraindicated. Anastrozole and Bazedoxifene-conjugated estrogens are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Estrogens in bazedoxifene/conjugated estrogens counteract the estrogen-lowering effect of anastrozole. Efficacy in breast cancer may be reduced.

How serious is the interaction between Anastrozole and Bazedoxifene-conjugated estrogens?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider non-estrogen alternatives.

What other medicines interact with Bazedoxifene-conjugated estrogens?

MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Ospemifene, Antithrombin alfa, Antithrombin iii. The full list is on the Bazedoxifene-conjugated estrogens page.

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