Interactions médicamenteuses
Bazedoxifene-conjugated estrogens + Dalteparin
Gravité: Majeure
Bazedoxifene-conjugated estrogens and Dalteparin: major interaction.
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Résumé
Conjugated estrogens and bazedoxifene both raise the risk of venous thromboembolism, which is exactly what dalteparin is given to prevent or treat. The prothrombotic estrogen effect may undermine anticoagulation, and the combination is generally inappropriate in active or prior VTE.
Ce que signifie cette interaction, en termes simples
Bazedoxifene-conjugated estrogens and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Dalteparin belongs to Cardiovascular.
Pourquoi elle survient
Estrogen and SERM-related prothrombotic changes (increased clotting factors, reduced antithrombin) counteract anticoagulant effect
Conduite à tenir
Avoid the estrogen/bazedoxifene combination in patients needing therapeutic anticoagulation for VTE; if prophylactic anticoagulation overlaps, reassess the need for hormone therapy.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contre-indiquée
- Bazedoxifene-conjugated estrogens + Ospemifene Contre-indiquée
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Majeure
- Antithrombin iii + Bazedoxifene-conjugated estrogens Majeure
- Bazedoxifene-conjugated estrogens + Bemiparin Majeure
- Bazedoxifene-conjugated estrogens + Carbamazepine Majeure
Autres interactions de Dalteparin
- Dalteparin + Defibrotide Contre-indiquée
- Dalteparin + Ketorolac Contre-indiquée
- Dalteparin + Mifepristone Contre-indiquée
- Abciximab + Dalteparin Majeure
- Acalabrutinib + Dalteparin Majeure
- Aceclofenac + Dalteparin Majeure
Questions fréquentes
Can I take Bazedoxifene-conjugated estrogens with Dalteparin?
MediHelp rates the interaction as major. Bazedoxifene-conjugated estrogens and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conjugated estrogens and bazedoxifene both raise the risk of venous thromboembolism, which is exactly what dalteparin is given to prevent or treat. The prothrombotic estrogen effect may undermine anticoagulation, and the combination is generally inappropriate in active or prior VTE.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the estrogen/bazedoxifene combination in patients needing therapeutic anticoagulation for VTE; if prophylactic anticoagulation overlaps, reassess the need for hormone therapy.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
