Drug interactions
Apomorphine + Dolasetron
Severity: Contraindicated
Apomorphine and Dolasetron: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. Dolasetron also prolongs the QT interval, adding an arrhythmia concern.
What this interaction means in plain words
Apomorphine and Dolasetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Mechanism of the hypotension is not established; additive QT prolongation is also possible.
What to do
Do not combine. Use a non-5-HT3 antiemetic such as domperidone or trimethobenzamide with apomorphine, according to local availability.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apomorphine and Dolasetron, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dolasetron
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
- Dolasetron + Ziprasidone Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
- Apomorphine + Palonosetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Dolasetron?
MediHelp rates the interaction as contraindicated. Apomorphine and Dolasetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. Dolasetron also prolongs the QT interval, adding an arrhythmia concern.
How serious is the interaction between Apomorphine and Dolasetron?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-5-HT3 antiemetic such as domperidone or trimethobenzamide with apomorphine, according to local availability.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Dolasetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
