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Interactions médicamenteuses

Dolasetron + Thioridazine

Gravité: Contre-indiquée

Dolasetron and Thioridazine: contraindicated interaction.

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Résumé

Thioridazine causes marked, dose-related QT prolongation and is itself associated with torsades de pointes. Adding dolasetron substantially increases the risk of fatal arrhythmia.

Ce que signifie cette interaction, en termes simples

Dolasetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dolasetron belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive potassium channel blockade producing marked QT prolongation.

Conduite à tenir

Do not combine; choose an antiemetic from a class without QT effects such as a dopamine antagonist alternative with low risk. Thioridazine labeling advises against use with other QT-prolonging agents.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dolasetron with Thioridazine?

MediHelp rates the interaction as contraindicated. Dolasetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked, dose-related QT prolongation and is itself associated with torsades de pointes. Adding dolasetron substantially increases the risk of fatal arrhythmia.

How serious is the interaction between Dolasetron and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antiemetic from a class without QT effects such as a dopamine antagonist alternative with low risk. Thioridazine labeling advises against use with other QT-prolonging agents.

What other medicines interact with Dolasetron?

MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.

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