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Interactions médicamenteuses

Cobicistat + Eletriptan

Gravité: Contre-indiquée

Cobicistat and Eletriptan: contraindicated interaction.

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Résumé

Cobicistat is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, which increases the risk of triptan toxicity including vasoconstriction and hypertension. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.

Ce que signifie cette interaction, en termes simples

Cobicistat and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cobicistat belongs to Miscellaneous; Eletriptan belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of CYP3A4-mediated metabolism of eletriptan, increasing its plasma concentrations.

Conduite à tenir

Do not use eletriptan during or within about 72 hours of cobicistat. Use a triptan not dependent on CYP3A4, such as rizatriptan or sumatriptan, if one is needed.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cobicistat with Eletriptan?

MediHelp rates the interaction as contraindicated. Cobicistat and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor and markedly raises eletriptan exposure, which increases the risk of triptan toxicity including vasoconstriction and hypertension. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.

How serious is the interaction between Cobicistat and Eletriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use eletriptan during or within about 72 hours of cobicistat. Use a triptan not dependent on CYP3A4, such as rizatriptan or sumatriptan, if one is needed.

What other medicines interact with Eletriptan?

MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.

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