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Interactions médicamenteuses

Arsenic trioxide + Moxifloxacin

Gravité: Contre-indiquée

Arsenic trioxide and Moxifloxacin: contraindicated interaction.

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Résumé

Arsenic trioxide causes QT prolongation and torsades de pointes and carries a boxed warning. Moxifloxacin adds further QT prolongation, so the combination should be avoided.

Ce que signifie cette interaction, en termes simples

Arsenic trioxide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Arsenic trioxide belongs to Oncology; Moxifloxacin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic QT prolongation.

Conduite à tenir

Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, keep potassium and magnesium replete and monitor ECGs frequently.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Arsenic trioxide with Moxifloxacin?

MediHelp rates the interaction as contraindicated. Arsenic trioxide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes QT prolongation and torsades de pointes and carries a boxed warning. Moxifloxacin adds further QT prolongation, so the combination should be avoided.

How serious is the interaction between Arsenic trioxide and Moxifloxacin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, keep potassium and magnesium replete and monitor ECGs frequently.

What other medicines interact with Moxifloxacin?

MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Disopyramide, Dofetilide. The full list is on the Moxifloxacin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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