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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Ibutilide + Moxifloxacin

Gravité: Contre-indiquée

Ibutilide and Moxifloxacin: contraindicated interaction.

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Résumé

Ibutilide strongly prolongs repolarization and carries a substantial risk of torsades de pointes. Adding moxifloxacin further increases QT prolongation and arrhythmia risk.

Ce que signifie cette interaction, en termes simples

Ibutilide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ibutilide belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Additive potassium channel blockade leading to delayed ventricular repolarization.

Conduite à tenir

Do not coadminister; use an alternative antibacterial while ibutilide is being used. Correct hypokalemia and hypomagnesemia and monitor ECG if exposure has occurred.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ibutilide with Moxifloxacin?

MediHelp rates the interaction as contraindicated. Ibutilide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide strongly prolongs repolarization and carries a substantial risk of torsades de pointes. Adding moxifloxacin further increases QT prolongation and arrhythmia risk.

How serious is the interaction between Ibutilide and Moxifloxacin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibacterial while ibutilide is being used. Correct hypokalemia and hypomagnesemia and monitor ECG if exposure has occurred.

What other medicines interact with Moxifloxacin?

MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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