Drug interactions
Arsenic trioxide + Moxifloxacin
Severity: Contraindicated
Arsenic trioxide and Moxifloxacin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide causes QT prolongation and torsades de pointes and carries a boxed warning. Moxifloxacin adds further QT prolongation, so the combination should be avoided.
What this interaction means in plain words
Arsenic trioxide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, keep potassium and magnesium replete and monitor ECGs frequently.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
- Ibutilide + Moxifloxacin Contraindicated
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes QT prolongation and torsades de pointes and carries a boxed warning. Moxifloxacin adds further QT prolongation, so the combination should be avoided.
How serious is the interaction between Arsenic trioxide and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, keep potassium and magnesium replete and monitor ECGs frequently.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Disopyramide, Dofetilide. The full list is on the Moxifloxacin page.
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