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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Arsenic trioxide + Octreotide

Gravité: Majeure

Arsenic trioxide and Octreotide: major interaction.

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Résumé

Arsenic trioxide carries a boxed warning for QT prolongation and torsades de pointes, and octreotide can add to this through bradycardia and QT effects. The combination raises the risk of serious ventricular arrhythmia.

Ce que signifie cette interaction, en termes simples

Arsenic trioxide and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Arsenic trioxide belongs to Oncology; Octreotide belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation, with octreotide-related bradycardia increasing torsades risk.

Conduite à tenir

Avoid the combination where possible. If it is necessary, obtain a baseline ECG, keep potassium and magnesium within normal range, and monitor ECG throughout therapy.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Arsenic trioxide with Octreotide?

MediHelp rates the interaction as major. Arsenic trioxide and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide carries a boxed warning for QT prolongation and torsades de pointes, and octreotide can add to this through bradycardia and QT effects. The combination raises the risk of serious ventricular arrhythmia.

How serious is the interaction between Arsenic trioxide and Octreotide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is necessary, obtain a baseline ECG, keep potassium and magnesium within normal range, and monitor ECG throughout therapy.

What other medicines interact with Octreotide?

MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Artemether / lumefantrine. The full list is on the Octreotide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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