Interactions médicamenteuses
Ceritinib + Octreotide
Gravité: Majeure
Ceritinib and Octreotide: major interaction.
Dernière mise à jour
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Résumé
Ceritinib prolongs the QT interval and can cause bradycardia, and octreotide has similar effects on heart rate and conduction. Together they may increase the risk of torsades de pointes.
Ce que signifie cette interaction, en termes simples
Ceritinib and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Octreotide belongs to Endocrine.
Pourquoi elle survient
Additive QTc prolongation and bradycardia.
Conduite à tenir
Avoid if possible; otherwise monitor ECG and electrolytes regularly and correct potassium and magnesium, reducing the ceritinib dose or interrupting it if QTc becomes markedly prolonged.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Octreotide
- Adagrasib + Octreotide Majeure
- Amisulpride + Octreotide Majeure
- Arsenic trioxide + Octreotide Majeure
- Artemether / lumefantrine + Octreotide Majeure
- Artemether + Octreotide Majeure
- Disopyramide + Octreotide Majeure
Autres interactions de Ceritinib
- Ceritinib + Cisapride Contre-indiquée
- Ceritinib + Eletriptan Contre-indiquée
- Ceritinib + Flibanserin Contre-indiquée
- Ceritinib + Pimozide Contre-indiquée
- Ceritinib + Thioridazine Contre-indiquée
- Ceritinib + Tolvaptan Contre-indiquée
Questions fréquentes
Can I take Ceritinib with Octreotide?
MediHelp rates the interaction as major. Ceritinib and Octreotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib prolongs the QT interval and can cause bradycardia, and octreotide has similar effects on heart rate and conduction. Together they may increase the risk of torsades de pointes.
How serious is the interaction between Ceritinib and Octreotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and electrolytes regularly and correct potassium and magnesium, reducing the ceritinib dose or interrupting it if QTc becomes markedly prolonged.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
