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Interactions médicamenteuses

Atazanavir + Desogestrel-ethinyl estradiol

Gravité: Majeure

Atazanavir and Desogestrel-ethinyl estradiol: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Atazanavir alters ethinyl estradiol exposure, and when boosted with ritonavir can reduce it, while progestin exposure may increase. This may lead to reduced contraceptive reliability, breakthrough bleeding, or progestin-related adverse effects.

Ce que signifie cette interaction, en termes simples

Atazanavir and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Atazanavir belongs to Anti Virals; Desogestrel-ethinyl estradiol belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Atazanavir inhibits CYP3A4 and UGT1A1, while ritonavir boosting induces glucuronidation, altering ethinyl estradiol and progestin levels.

Conduite à tenir

Use a contraceptive containing at least 30 mcg ethinyl estradiol with unboosted atazanavir, or choose an alternative or additional non-hormonal method. Avoid products with less than 30 mcg ethinyl estradiol with boosted atazanavir.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atazanavir with Desogestrel-ethinyl estradiol?

MediHelp rates the interaction as major. Atazanavir and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir alters ethinyl estradiol exposure, and when boosted with ritonavir can reduce it, while progestin exposure may increase. This may lead to reduced contraceptive reliability, breakthrough bleeding, or progestin-related adverse effects.

How serious is the interaction between Atazanavir and Desogestrel-ethinyl estradiol?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a contraceptive containing at least 30 mcg ethinyl estradiol with unboosted atazanavir, or choose an alternative or additional non-hormonal method. Avoid products with less than 30 mcg ethinyl estradiol with boosted atazanavir.

What other medicines interact with Desogestrel-ethinyl estradiol?

MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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