Interactions médicamenteuses
Belzutifan + Desogestrel-ethinyl estradiol
Gravité: Majeure
Belzutifan and Desogestrel-ethinyl estradiol: major interaction.
Dernière mise à jour
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Résumé
Belzutifan is a weak CYP3A4 inducer and may lower hormonal contraceptive concentrations, which can cause contraceptive failure or breakthrough bleeding. Belzutifan is also teratogenic, so reliable contraception is essential.
Ce que signifie cette interaction, en termes simples
Belzutifan and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Belzutifan belongs to Miscellaneous; Desogestrel-ethinyl estradiol belongs to Endocrine.
Pourquoi elle survient
Induction of CYP3A4 by belzutifan increases metabolism of contraceptive steroids.
Conduite à tenir
Use an effective non-hormonal contraceptive method during belzutifan treatment and for the period specified in labeling after the last dose. Do not rely on hormonal contraceptives alone.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contre-indiquée
- Aminocaproic acid + Desogestrel-ethinyl estradiol Majeure
- Amobarbital + Desogestrel-ethinyl estradiol Majeure
- Anastrozole + Desogestrel-ethinyl estradiol Majeure
- Apalutamide + Desogestrel-ethinyl estradiol Majeure
- Atazanavir + Desogestrel-ethinyl estradiol Majeure
Autres interactions de Belzutifan
Questions fréquentes
Can I take Belzutifan with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Belzutifan and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Belzutifan is a weak CYP3A4 inducer and may lower hormonal contraceptive concentrations, which can cause contraceptive failure or breakthrough bleeding. Belzutifan is also teratogenic, so reliable contraception is essential.
How serious is the interaction between Belzutifan and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive method during belzutifan treatment and for the period specified in labeling after the last dose. Do not rely on hormonal contraceptives alone.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
