Interactions médicamenteuses
Anastrozole + Desogestrel-ethinyl estradiol
Gravité: Majeure
Anastrozole and Desogestrel-ethinyl estradiol: major interaction.
Dernière mise à jour
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Résumé
Anastrozole works by lowering estrogen levels, and exogenous estrogen such as ethinyl estradiol opposes this effect. The combination undermines the therapeutic aim in hormone-receptor-positive breast cancer, and anastrozole is not intended for use in premenopausal women who might need contraception.
Ce que signifie cette interaction, en termes simples
Anastrozole and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anastrozole belongs to Oncology; Desogestrel-ethinyl estradiol belongs to Endocrine.
Pourquoi elle survient
Pharmacodynamic antagonism: exogenous estrogen counteracts aromatase inhibition-induced estrogen suppression.
Conduite à tenir
Avoid combined estrogen-containing products in patients taking anastrozole; use a non-hormonal contraceptive if contraception is needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contre-indiquée
- Aminocaproic acid + Desogestrel-ethinyl estradiol Majeure
- Amobarbital + Desogestrel-ethinyl estradiol Majeure
- Apalutamide + Desogestrel-ethinyl estradiol Majeure
- Atazanavir + Desogestrel-ethinyl estradiol Majeure
- Belzutifan + Desogestrel-ethinyl estradiol Majeure
Autres interactions de Anastrozole
- Anastrozole + Bazedoxifene / conjugated estrogens Contre-indiquée
- Anastrozole + Bazedoxifene-conjugated estrogens Contre-indiquée
- Anastrozole + Conjugated estrogens Contre-indiquée
- Anastrozole + Estradiol Contre-indiquée
- Anastrozole + Estrogens conjugated synthetic Contre-indiquée
- Anastrozole + Estrogens esterified Contre-indiquée
Questions fréquentes
Can I take Anastrozole with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Anastrozole and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anastrozole works by lowering estrogen levels, and exogenous estrogen such as ethinyl estradiol opposes this effect. The combination undermines the therapeutic aim in hormone-receptor-positive breast cancer, and anastrozole is not intended for use in premenopausal women who might need contraception.
How serious is the interaction between Anastrozole and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined estrogen-containing products in patients taking anastrozole; use a non-hormonal contraceptive if contraception is needed.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
