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Interactions médicamenteuses

Atenolol + Bismuth subsalicylate

Gravité: Modérée

Atenolol and Bismuth subsalicylate: moderate interaction.

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Résumé

Bismuth subsalicylate releases salicylate, which may inhibit renal prostaglandin synthesis, causing sodium and water retention and blunting the antihypertensive effect of beta-blockers. The effect is chiefly seen with regular high-dose salicylate use and is generally modest with short courses.

Ce que signifie cette interaction, en termes simples

Atenolol and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Atenolol belongs to Cardiovascular; Bismuth subsalicylate belongs to Gastrointestinal Tract.

Niveau de preuve: Low

Pourquoi elle survient

Salicylate inhibits prostaglandin synthesis, causing sodium and fluid retention that opposes the antihypertensive effect.

Conduite à tenir

Limit bismuth subsalicylate to short courses and monitor blood pressure if used repeatedly. Use an alternative antidiarrheal or antacid for prolonged treatment.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atenolol with Bismuth subsalicylate?

MediHelp rates the interaction as moderate. Atenolol and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth subsalicylate releases salicylate, which may inhibit renal prostaglandin synthesis, causing sodium and water retention and blunting the antihypertensive effect of beta-blockers. The effect is chiefly seen with regular high-dose salicylate use and is generally modest with short courses.

How serious is the interaction between Atenolol and Bismuth subsalicylate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit bismuth subsalicylate to short courses and monitor blood pressure if used repeatedly. Use an alternative antidiarrheal or antacid for prolonged treatment.

What other medicines interact with Bismuth subsalicylate?

MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.

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