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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Atracurium + Corticotropin

Gravité: Modérée

Atracurium and Corticotropin: moderate interaction.

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Résumé

Corticotropin stimulates endogenous corticosteroid release, and corticosteroids given with nondepolarizing neuromuscular blockers have been linked to acute quadriplegic myopathy, especially in critically ill patients on prolonged infusions. Risk is greatest with prolonged ventilation and high steroid exposure.

Ce que signifie cette interaction, en termes simples

Atracurium and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Atracurium belongs to Musculoskeletal; Corticotropin belongs to Endocrine.

Niveau de preuve: Low

Pourquoi elle survient

Additive muscle toxicity from corticosteroid-induced myopathy and prolonged neuromuscular blockade; the exact mechanism is not fully established.

Conduite à tenir

Limit the duration and dose of neuromuscular blockade in patients receiving corticotropin, and monitor for persistent weakness and creatine kinase elevation.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atracurium with Corticotropin?

MediHelp rates the interaction as moderate. Atracurium and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates endogenous corticosteroid release, and corticosteroids given with nondepolarizing neuromuscular blockers have been linked to acute quadriplegic myopathy, especially in critically ill patients on prolonged infusions. Risk is greatest with prolonged ventilation and high steroid exposure.

How serious is the interaction between Atracurium and Corticotropin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration and dose of neuromuscular blockade in patients receiving corticotropin, and monitor for persistent weakness and creatine kinase elevation.

What other medicines interact with Atracurium?

MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.

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