Interactions médicamenteuses
Atropine + Glycopyrronium
Gravité: Modérée
Atropine and Glycopyrronium: moderate interaction.
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Résumé
Both drugs are antimuscarinic agents, so combining them adds to anticholinergic effects such as dry mouth, tachycardia, urinary retention, constipation, blurred vision and confusion. Older or frail patients are most vulnerable to these additive effects.
Ce que signifie cette interaction, en termes simples
Atropine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Glycopyrronium belongs to Respiratory.
Pourquoi elle survient
Additive pharmacodynamic blockade of muscarinic acetylcholine receptors.
Conduite à tenir
Avoid routine duplication of antimuscarinics and monitor heart rate, bowel and bladder function, and mental status if both are required. Reduce the dose of one agent if anticholinergic toxicity appears.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Glycopyrronium
- Clozapine + Glycopyrronium Majeure
- Abobotulinumtoxina + Glycopyrronium Modérée
- Aclidinium + Glycopyrronium Modérée
- Amantadine + Glycopyrronium Modérée
- Amitriptyline + Glycopyrronium Modérée
- Amoxapine + Glycopyrronium Modérée
Autres interactions de Atropine
- Atropine + Eluxadoline Majeure
- Atropine + Henbane Majeure
- Atropine + Pramlintide Majeure
- Abobotulinumtoxina + Atropine Modérée
- Aclidinium + Atropine Modérée
- Amantadine + Atropine Modérée
Questions fréquentes
Can I take Atropine with Glycopyrronium?
MediHelp rates the interaction as moderate. Atropine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antimuscarinic agents, so combining them adds to anticholinergic effects such as dry mouth, tachycardia, urinary retention, constipation, blurred vision and confusion. Older or frail patients are most vulnerable to these additive effects.
How serious is the interaction between Atropine and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of antimuscarinics and monitor heart rate, bowel and bladder function, and mental status if both are required. Reduce the dose of one agent if anticholinergic toxicity appears.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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