Référentiel des médicaments
Glycopyrronium
Glycopyrronium is a medicine in the class respiratory. It is used for copd.
- Classe médicamenteuse: Respiratory
- Indications: copd
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Respiratory
- Code ATC
- R03BB06, A03AB02
- Formes courantes
- inhalateur, injection
- Dosages courants
- 50 mcg, 1 mg/5 ml, 2.4 g/100 g
- Interactions connues
- 107 (Majeure: 1 · Modérée: 88 · Mineure: 18)
- Noms commerciaux
- 10
- Pays et marchés
- 5
Indications
Mécanisme d'action
Long-acting muscarinic antagonist (LAMA); often referred to as an anticholinergic; produces bronchodilation by inhibiting acetylcholine’s effect on muscarinic receptors in the airway smooth muscle.
Posologie adulte habituelle (résumé de la notice)
Surgery (Preoperative): 4mcg/kg IM 30-60 min before surgery. (Intraoperative): 0.1 mg IV; may repeat q2-3min
Grossesse et allaitement
- Grossesse
- Unknown Injection: very little crosses the placenta; widely used in anaesthesia, including caesarean section, without fetal heart effects. Oral and inhaled forms: no human data; no birth defects in rats or rabbits. Some UK injection labels: not recommended. Use only if clearly needed.
- Allaitement
- Safe No milk data; it is poorly absorbed by the infant (quaternary drug). Single doses (e.g. anaesthesia) and inhaled or skin use are unlikely to matter. Long-term oral use may reduce milk supply; watch the infant's weight gain.
Effets indésirables signalés
- Upper respiratory tract infection
- Nasopharyngitis
- Oropharyngeal pain
Contre-indications
- Hypersensitivity to drug or components
- Glaucoma
- Obstructive uropathies, including prostatic hypertrophyMechanical obstructive diseases of gastrointestinal tract (eg, pyloroduodenalstenosis, strictures)
Principales interactions (107)
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
- Atropine + Glycopyrronium Moderate
- Atropine iv / + Glycopyrronium Moderate
- Belladonna alkaloids + Glycopyrronium Moderate
- Belladonna and opium + Glycopyrronium Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Glycopyrronium used for?
Glycopyrronium is a medicine in the class respiratory. It is used for COPD.
What side effects have been reported with Glycopyrronium?
Upper respiratory tract infection, Nasopharyngitis, Oropharyngeal pain.
Can Glycopyrronium be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Injection: very little crosses the placenta; widely used in anaesthesia, including caesarean section, without fetal heart effects. Oral and inhaled forms: no human data; no birth defects in rats or rabbits. Some UK injection labels: not recommended. Use only if clearly needed. Breastfeeding: Safe. No milk data; it is poorly absorbed by the infant (quaternary drug). Single doses (e.g. anaesthesia) and inhaled or skin use are unlikely to matter. Long-term oral use may reduce milk supply; watch the infant's weight gain.
What does Glycopyrronium interact with?
MediHelp lists 107 known interactions for Glycopyrronium. Major: 1 · Moderate: 88 · Minor: 18. The most serious include Clozapine, Abobotulinumtoxina, Aclidinium.
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